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A new stem cell bandage could help in cartilage regeneration

By Rob Aid
2 Comments18 June 2011

knee-cartilage_0Millions of people with knee injuries could benefit from a new type of stem cell bandage treatment if clinical trials prove successful. The world’s first clinical trial for the treatment of patients with torn meniscal cartilage has received approval from the MHRA (UK regulatory agency). The current treatment for the majority of tears is the removal of the meniscus, a procedure that often results in the early onset of osteoarthritis.

Meniscus tears normally occur in active and younger people (estimated 80 percent of meniscal patients are younger than 50) and it is a common sports injury among the competitive athletes. Unlike the researchers from Northwestern University who are creating a gel which helps in cartilage regeneration, the Phase I trial, one of the first in the UK to be approved using stem cells, will treat meniscal tear patients with a cell bandage product which is seeded with the patient’s own stem cells.

The cell bandage, produced by Azellon Ltd, a University of Bristol spin-out company, is focused on the research, development and commercialization of an adult autologous (patient’s own) stem cell technology which in vitro (tissue culture) has shown great promise for the healing of meniscal tears.

“The approval we have received from the MHRA is an important milestone in the development of stem cell therapies in the UK. These cells hold much scientific and medical promise but we can only know if they work or not by testing them out in clinical trials”, said Professor Anthony Hollander, Chief Scientific Officer at Azellon Ltd and Head of the School of Cellular and Molecular Medicine at the University of Bristol.

The trial is designed primarily to test the safety profile of Azellon’s cell bandage in ten meniscal tear patients. The bandage, containing the patient’s own stem cells will be implanted in a simple surgical procedure using a specially designed instrument to deliver the cells into the injured site as a first-line treatment in place of removal of the meniscus.  Patients will be closely monitored for safety over a five-year follow-up period.

“The effective repair of meniscal tears would represent a significant advance in treatment, particularly for younger patients and athletes by reducing the likelihood of early onset osteoarthritis, and would offer an exciting new treatment option for surgeons”, said Professor Ashley Blom, Professor of Orthopaedic Surgery at the University of Bristol.

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2 Comments — Leave your response!

  • Andreas Koertig
     

    My brother suggested I might like this blog. He used to be entirely right. This submit truly made my day. You can not consider simply how much time I had spent for this info! Thanks!

  • Ashish Agarwal
     

    this procedure should have been developed long back. when tissues culture can grow tissues researcher should focus on regeneration of damaged or torn tissues either inside the body or cultivating them outside the body and then implant it.

    My best wishes!

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